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20. atorvastatin price in usa NCCIH–ClinicalTrials.gov
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1. Cancer Drug: atorvastatin/clopidogrel
2. Number of participants: 1179
3. Clinical Trial Start Date: April 2006
Clinical Trial End Date: July 2011
Total number of participants: 1179
Total investigator(s): 718
Sponsoring Agency: NCCIH, Jonsson Comprehensive Cancer Center, University of California, Los Angeles
Sponsoring Institution(s): National Cancer Institute
Primary Purpose: Treatment The outcome is change in anti-angiogenin (AE) concentration that is monitored over 90 days with clopidogrel and atorvastatin
and Anti-angiogenic activity of clopidogrel atorvastatin over 90 days without concomitant treatment is studied in a randomized, open-label, crossover design
and Anti-angiogenic activity is studied in a randomized, open-label, crossover design Safety is Online coupons canada drug pharmacy assessed using overall survival and clinical events.
AE changes over 90 days from baseline: No statistically significant difference was found between no- and with-concomitant treatment at baseline. For clopidogrel and atorvastatin, there were no statistically significant differences between treatment groups in the frequency of treatment-related adverse events (AEs). For clopidogrel and atorvastatin, the differences were statistically significant (P<.001).
Safety was evaluated in 2 doses, 200 mg and 400 mg, as compared for the 2 dose combinations with 1 to 2 doses per week of clopidogrel and atorvastatin to achieve a target of 60 mg and 30 mg. The numbers of participants reporting at least 1 treatment-associated AEs were similar between treatment groups.
ClinicalTrials.gov and for the combination of atorvastatin 20 g/6 g and of clopidogrel 40 mg/20 mg provided similar safety and efficacy data.
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What are the most commonly reported side effects of atorvastatin?
In clinical trials, the most common side effects of atorvastatin reported in the US and worldwide included dizziness, nausea or vomiting, headache, fatigue, decreased appetite and dizziness, anxiety, dyspepsia, increased blood pressure, and low levels of the co-active drug statins. Atorvastatin was generally well tolerated.
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Does atorvastatin meet guidelines as part of my cancer treatment?
Atorvastatin is recommended for the prevention of cardiovascular disease due to reduction in risk of ischemic stroke, myocardial infarction, and transient ischemic attack
The FDA approved use of atorvastatin in patients at risk cost of atorvastatin 40 mg without insurance for cardiovascular disease. The most recent review included a total of 24 RCTs (randomized, placebo-controlled trials) and more than 1,300 total patient admissions; the dose range varied from 12 to 400 mg daily. There were no significant differences that could be detected among the treatments all of them when evaluated with respect to baseline characteristics, cardiovascular endpoints, or clinical outcomes. In general, patients who were treated with atorvastatin had less than 10% of the amount cholesterol and triglycerides predicted to be present in this patient population [see ADVERSE REACTIONS AND NON-SURVEILLANCE STUDIES]. There may be an unfavorable response to the drug for some patients. (see Boxed WARNING)
Atorvastatin may worsen preexisting heart disease. The primary objective of treatment individuals in these groups is prevention of cardiovascular disease, but atorvastatin may worsen preexisting heart disease because such patients may need more frequent blood draws or be prescribed other Terbinafine hydrochloride cream for balanitis drugs to control blood pressure. Furthermore, more frequent draws may lead to a higher risk of bleeding and a less desirable clinical outcome for many patients. Because of the potential risk bleeding, patients with heart disease should be specifically evaluated prior to starting treatment and should be counseled about the safety of taking anti-hypertensive or lipid-lowering drugs that are required to reduce blood pressure. Patients with known or suspected cardiovascular disease should be advised of the need to be very careful with regard to the use of blood pressure–lowering drugs.
Adverse Reactions Associated With Statin Dose Modification
The is generic atorvastatin the same as lipitor following side effects may occur after treatment with statins and when taken at higher doses of atorvastatin or clopidogrel:.
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